Fair‐Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration

Lipoxins (LXs) are autacoids, specialized proresolving lipid mediators (SPMs) acting locally in a paracrine or autocrine fashion. They belong to a complex superfamily of dietary small polyunsaturated fatty acid (PUFA)–metabolites, which direct potent cellular responses to resolve inflammation and restore tissue homeostasis. Together, these SPM activities have been intensely studied in systemic inflammation and acute injury or infection, but less is known about LX signaling and activities in the central nervous system. LXs are derived from arachidonic acid, an omega‐6 PUFA. In addition to well‐established roles in systemic inflammation resolution, they have increasingly become implicated in regulating neuroinflammatory and neurodegenerative processes. In particular, chronic inflammation plays a central role in Alzheimer's disease (AD) etiology, and dysregulated LX production and activities have been reported in a variety of AD rodent models and clinical tissue samples, yet with complex and sometimes conflicting results. In addition, reduced LX production following retinal injury has been reported recently by the authors, and an intriguing direct neuronal activity promoting survival and homeostasis in retinal and cortical neurons is demonstrated. Here, the authors review and clarify this growing literature and suggest new research directions to further elaborate the role of lipoxins in neurodegeneration.     

Gasification biochar as a valuable by-product for carbon sequestration and soil amendment

Thermal gasification of various biomass residues is a promising technology for combining bioenergy production with soil fertility management through the application of the resulting biochar as soil amendment. In this study, we investigated gasification biochar (GB) materials originating from two major global biomass fuels: straw gasification biochar (SGB) and wood gasification biochar (WGB), produced by a Low Temperature Circulating Fluidized Bed gasifier (LT-CFB) and a TwoStage gasifier, respectively, optimized for energy conversion. Stability of carbon in GB against microbial degradation was assessed in a short-term soil incubation study and compared to the traditional practice of direct incorporation of cereal straw. The GBs were chemically and physically characterized to evaluate their potential to improve soil quality parameters. After 110 days of incubation, about 3% of the added GB carbon was respired as CO₂, compared to 80% of the straw carbon added. The stability of GB was also confirmed by low H/C and O/C atomic ratios with lowest values for WGB (H/C 0.12 and O/C 0.10). The soil application of GBs exhibited a liming effect increasing the soil pH from ca 8 to 9. Results from scanning electron microscopy and BET analyses showed high porosity and specific surface area of both GBs, indicating a high potential to increase important soil quality parameters such as soil structure, nutrient and water retention, especially for WGB. These results seem promising regarding the possibility to combine an efficient bioenergy production with various soil aspects such as carbon sequestration and soil quality improvements.     

Predicting the settlement of geosynthetic-reinforced soil foundations using evolutionary artificial intelligence technique

In order to ensure safe and sustainable design of geosynthetic-reinforced soil foundation (GRSF), settlement prediction is a challenging task for practising civil/geotechnical engineers. In this paper, a new hybrid technique for predicting the settlement of GRSF has been proposed based on the combination of evolutionary algorithm, that is, grey-wolf optimisation (GWO) and artificial neural network (ANN), abbreviated as ANN-GWO model. For this purpose, the reliable pertinent data were generated through numerical simulations conducted on validated large-scale 3-D finite element model. The predictive power of the model was assessed using various well-established statistical indices, and also validated against several independent scientific studies as reported in literature. Furthermore, the sensitivity analysis was conducted to examine the robustness and reliability of the model. The results as obtained have indicated that the developed hybrid ANN-GWO model can estimate the maximum settlement of GRSF under service loads in a reliable and intelligent way, and thus, can be deployed as a predictive tool for the preliminary design of GRSF. Finally, the model was translated into functional relationship which can be executed without the need of any expensive computer-based program.     

Seismic behavior of geosynthetic-reinforced retaining walls backfilled with cohesive soil

This study investigates the seismic performance of geosynthetic-reinforced modular block retaining walls backfilled with cohesive, fine grained clay-sand soil mixture. Shaking table tests were performed for three ½ scaled (wall height 190 cm) and ¼ scaled model walls to investigate the effects of backfill type, the influence of reinforcement length and reinforcement stiffness effects. The El Centro and Kobe earthquake records of varying amplitudes were used as base acceleration. Displacement of the front wall, accelerations at different locations, strains on the reinforcements, and the visual observations of the facing and the backfill surface were used to evaluate the seismic performance of model walls. The model walls were subjected to rigorous shaking and the walls did not exhibit any stability problems or signs of impending failure. The maximum deformations observed on the models with cohesive backfill was less than half of the deformation of the sand model. The load transfers between the geogrid and cohesive soil was comparable to that of sand and hence the needed reinforcement length was similar as well. As a result; the model walls with cohesive backfills performed within acceptable limits under seismic loading conditions when compared with granular backfilled counterparts.     

Three-dimensional finite element analysis of geosynthetic-reinforced soil walls with turning corners

The paper presents in-depth three-dimensional finite element analyses investigating geosynthetic-reinforced soil walls with turning corners. Validation of the 3D numerical procedure was first performed via comparisons between the simulated and reported results of a benchmark physical modeling built at the Royal Military College of Canada. GRS walls with corners of 90°, 105°, 120°, 135°, 150°, and 180° were simulated adopting the National Concrete Masonry Association guidelines. The behaviors of the GRS walls with corners, including the lateral facing displacement, maximum reinforcement load, factor of safety, potential failure surface, vertical separation of facing blocks, and types of corners were carefully evaluated. Our comprehensive results show (i) minimum lateral displacement occurs at the corner; (ii) lower strength of reinforcements are required at the corner; (iii) higher corner angles lead to lower stability; (iv) potential failure surface forms earlier at the end walls; (v) deeper potential failure surfaces are found at the corners; (vi) larger numbers of vertical separations are found at walls with smaller corner angles. The paper highlighted the salient influence of the corners on the behaviors of GRS walls and indicated that a 3D analysis could reflect the required reinforcement length and the irregular formation of the potential failure surfaces.     

Large-scale load capacity tests on a geosynthetic encased column

Stone columns have been used to minimize the settlement of embankments on soft soils but their use in very soft soils can become challenging, partly because of the low confinement provided by the surrounding soil. Geosynthetic encased columns (GECs) have been successfully used to enhance to reduce settlements of embankments on soft soils. This paper describes an investigation on the performance of encased columns constructed on a very soft soil using different types of encasement (three woven geotextiles with different values of tensile stiffness) and different column fill materials (sand, gravel and recycled construction and demolition waste, RCDW). The results of load capacity tests conducted on large-scale models constructed to simulate the different types of GECs indicate that the displacement method adopted during column installation can lead to an enhanced shear strength in the smear zone that develops within the very soft soil. In addition, breakage of the column fill material was found to affect the load-settlement response of gravel and RCDW columns. Furthermore, the excess pore water pressure generated in the surrounding soil during installation, was found to remain limited to radial distances smaller than three times the GEC diameter.     

Post-erosion mechanical responses of internally unstable gap-graded soil under drained torsional simple shear and triaxial compression

Internal erosion is a major threat to hydraulic earth structures, such as river levees and dams. This paper focuses on suffusion and suffosion phenomena which are caused by the movement of fine particles in the granular skeleton due to seepage flow. The present study investigates the impact of internal erosion on the dynamic response under cyclic torsional shear and monotonic responses under triaxial compression and torsional simple shear. A series of experiments, using a gap-graded silica mixture with a fines content of 20%, is performed under loose, medium, and dense conditions using a novel erosion hollow cylindrical torsional shear apparatus. The erosion test results indicate that the critical hydraulic gradient and the rate of erosion are density-dependent, where a transition from suffosion to suffusion is observed as the seepage continues. Regardless of the sample density, variations in the radial strain and particle size distribution, along the specimen height after erosion, are no longer uniform. Furthermore, the dynamic shearing results show that the small-strain shear modulus increases, but the initial damping ratio decreases after internal erosion, probably due to the removal of free fines. In addition, the elastic threshold strain and reference shear strain values are found to be higher for the eroded and non-eroded specimens, respectively. Finally, based on drained monotonic loading, the post-erosion peak stress ratio increases remarkably under triaxial compression, while that under torsional simple shear depends on the relative density where the direction of loading is normal to the direction of seepage. These observations indicate that the horizontal bedding plane becomes weaker, while the vertical one becomes stronger after downward erosion.     

Stability assessment of 3D reinforced soil structures under steady unsaturated infiltration

Internal stability assessment of geosynthetic-reinforced soil structures (GRSSs) has been commonly carried out assuming plane-strain conditions and dry backfills. However, failures of GRSSs usually show three-dimensional (3D) features and occur under unsaturated conditions. A procedure based on the kinematic limit-analysis method is proposed herein to assess 3D effects and the role of steady unsaturated infiltration on the required geosynthetic strength for GRSSs. A suction stress-based framework is used to describe the soil stress behavior under steady unsaturated infiltration. Based on the principle of energy-work balance, the required geosynthetic strength is determined. A comparison analysis with the prior research is conducted to verify the developed method. Two kinds of backfills, i.e., high-quality backfill and marginal backfill, are considered for comparison in this work. It is shown that accounting for 3D effects and the role of unsaturated infiltration considerably reduces the required geosynthetic strength. The 3D effects are primarily affected by the width-to-height ratio of GRSSs, and the contribution of unsaturated infiltration is mainly influenced by the soil type, flow rate, GRSS's height, and location of the water table.